Natural product bioactive peptide discovery using PepSAVI‐MS
نویسندگان
چکیده
منابع مشابه
The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery.
The recent increase in extensively drug-resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for new antibiotic backbones with novel mechanisms of action. Here, we report the development of the PepSAVI-MS pipeline for bioactive peptide discovery. This highly versatile platform employs mass spectrometry and statistics to identify bio...
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Food-protein derived bioactive peptides are short amino acid chains that are inactive within the sequence of the parent protein, but can be released through hydrolysis by proteolytic enzymes. Several physiological effects have been attributed to these peptides, such as blood pressure reduction, scavenging of oxidative compounds, induction of satiety and reduction of cholesterol. Due to their ab...
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The Natural Product Discovery Institute contains a set of more than 30 000 fungal and actinomycete organisms that can be used for natural product discovery. The natural product library contains purified compounds, partially purified column fractions, and crude extracts from natural product-producing organisms. The collection is available for screening. This site describes a roadmap for analysin...
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helping me to resolve the questions I had. Our meetings, sometimes together with Peter, were always very constructive and taught me to evaluate my results critically. día! Angela thank you for doing some microinjections for me and the nice times together! Tatiana, thanks for the nice collaboration on the AEDs-PTZ paper and all the EEG data. Olivia thank you for proofreading this manuscript. San...
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Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently ge...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2018
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2018.32.1_supplement.120.1